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Homocysteine and lipid levels in young patients with coronary artery disease

A Puri1, O K Gupta, R N Dwivedi

  • 1KPS Post Graduate Institute of Medicine; +Professor and Head, LPS Institute of Cardiology, GSVM Medical College, Kanpur.

The Journal of the Association of Physicians of India
|November 19, 2003
PubMed

Insights

Elevated homocysteine is a significant independent risk factor for premature coronary artery disease (CAD) in young Indian patients. This novel risk factor should be evaluated, especially when traditional risk factors are absent.

Area of Science:

  • Cardiovascular Medicine
  • Biochemistry
  • Public Health

Background:

  • Coronary artery disease (CAD) affects Indians prematurely.
  • Homocysteine is a recognized risk factor for CAD.
  • The role of homocysteine in young Indian CAD patients requires further investigation.

Purpose of the Study:

  • To determine the independent association of homocysteine with traditional risk factors in young Indian CAD patients.
  • To highlight the importance of homocysteine as a novel risk factor in this population.

Main Methods:

  • Study included 51 young CAD patients (< 45 years) and 15 healthy controls.
  • Patients were divided into hyperlipidemic and normolipidemic subgroups.
  • Plasma homocysteine levels were measured using high-pressure liquid chromatography.

Main Results:

  • Mean homocysteine levels were significantly higher in CAD patients (27.8 nmol/ml) compared to controls (13.22 nmol/ml).
  • Over 72% of young CAD patients had homocysteine levels above the cut-off (18 nmol/ml).
  • Homocysteine levels were elevated regardless of the patient's lipid profile.

Conclusions:

  • Plasma homocysteine is a significant independent risk factor for premature CAD in young Indians.
  • Homocysteine evaluation is recommended for young CAD patients, particularly those without traditional risk factors.
  • The findings underscore the need to recognize homocysteine's role in cardiovascular risk stratification.
Abstract

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