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RS-61443 reverses acute renal allograft rejection in dogs

K P Platz1, W O Bechstein, D E Eckhoff

  • 1Department of Surgery, University of Wisconsin School of Medicine, Madison, Wisconsin 53792, USA.

Transplant International : Official Journal of the European Society for Organ Transplantation
|January 1, 1992
PubMed

RS-61443 is a noncompetitive allosteric inhibitor of inosine monophosphate dehydrogenase. It blocks the proliferative response of T and B lymphocytes, prevents the generation of cytotoxic T cells, and inhibits antibody formation. This study was conducted to see whether or not RS-61443 can reverse acute renal allograft rejection in dogs. It was possible to reverse this process.

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