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Oral ketamine for opioid-resistant acute pain
R Friedman1, J Jallo, W F Young
1Department of Anesthesiology, Temple University, and the Temple Neurospine Program, Temple University Hospital, Philadelphia, PA 19140, USA. freidmr@tuhs.temple.edu
The Journal of Pain
|November 19, 2003
Summary
This case report shows oral ketamine effectively treated postoperative pain resistant to opioids. Ketamine helped reduce opioid dosage requirements, suggesting potential for combined therapies.
Area of Science:
- Anesthesiology
- Pain Management
- Pharmacology
Background:
- Postoperative pain management presents challenges, particularly opioid-resistant cases.
- Opioid analgesics are standard but associated with side effects and tolerance.
- N-methyl-D-aspartate (NMDA) receptor antagonists show promise in modulating pain pathways.
Purpose of the Study:
- To report the successful use of oral ketamine in managing opioid-resistant postoperative pain.
- To evaluate the efficacy of ketamine in reducing opioid requirements for pain control.
Main Methods:
- A case report detailing the treatment of a patient with severe postoperative pain.
- Administration of oral ketamine as an adjunct to opioid therapy.
- Monitoring of pain levels and opioid consumption.
Main Results:
- Oral ketamine administration led to successful pain control.
- A significant reduction in the required dosage of opioid analgesics was observed.
- The patient experienced improved pain management without escalating opioid use.
Conclusions:
- Oral ketamine is a viable option for treating opioid-resistant postoperative pain.
- Combining opioids with NMDA receptor antagonists like ketamine warrants further investigation for acute pain.
- This approach may offer a safer and more effective strategy for managing challenging pain scenarios.