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Collagens--structure, function, and biosynthesis.

K Gelse1, E Pöschl, T Aigner

  • 1Cartilage Research, Department of Pathology, University of Erlangen-Nürnberg, Krankenhausstr. 8-10, D-91054 Erlangen, Germany.

Advanced Drug Delivery Reviews
|November 19, 2003
PubMed
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This review explores collagens, the most abundant extracellular matrix proteins. It details their distribution, function, biosynthesis, and therapeutic potential in various tissues and diseases.

Area of Science:

  • Biochemistry
  • Cell Biology
  • Biotechnology

Background:

  • The extracellular matrix (ECM) is crucial for tissue structure and function, composed of diverse proteins.
  • Collagens are the most abundant protein family in the ECM, with over 20 identified types.
  • Collagens form essential fibrillar and microfibrillar networks, basement membranes, and other ECM structures.

Purpose of the Study:

  • To review the distribution and function of various collagen types across different tissues.
  • To introduce the basic structural subunits of collagens.
  • To outline the biosynthesis and supramolecular processing of fibrillar collagens.

Main Methods:

  • Literature review focusing on collagen structure, function, and biosynthesis.
  • Analysis of collagen distribution and roles in diverse tissue types.

Related Experiment Videos

  • Examination of fibrillar collagen processing and therapeutic applications.

    • Main Results:

    • Collagens are key structural components of the ECM, vital for tissue integrity.
    • Over 20 collagen types exist, each with specific distributions and functions.
    • Fibrillar collagens, as prototypical members, undergo complex biosynthesis and processing.

    Conclusions:

    • Understanding collagen types is essential for comprehending collagen-related diseases.
    • Collagens serve as a basis for developing novel therapeutic strategies.
    • Further research into collagen function and processing can unlock new treatments.