Related Experiment Videos
Review: Derivatization in mass spectrometry--2. Acylation
Vladimir G Zaikin1, John M Halket
1Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences, Moscow, Russia. zaikin@ips.ac.ru
European Journal of Mass Spectrometry (Chichester, England)
|November 19, 2003
Summary
Acylation is a key derivatization technique used to protect OH, SH, and NH groups, enhancing volatility and chromatographic properties for analysis. This review covers its chemical aspects, mass spectral properties, and diverse analytical applications.
Area of Science:
- Analytical Chemistry
- Organic Chemistry
- Mass Spectrometry
Background:
- Acylation is a common derivatization method for compounds containing hydroxyl (OH), thiol (SH), and amine (NH) functional groups.
- Protecting these groups enhances sample volatility and chromatographic behavior, crucial for effective analysis.
- Derivatization aims to improve mass spectral properties for better identification and quantification.
Purpose of the Study:
- To review the chemical principles and applications of acylation as a derivatization technique.
- To discuss the characteristics of various acylating agents and their impact on derivative properties.
- To explore the utility of mass spectrometry (EI, CI, NI-CI) in analyzing acylated derivatives.
Main Methods:
- Characterization of chemical aspects of acylation reactions.
- Evaluation of different acylating agents for derivatization.
- Analysis of mass spectral data (EI, CI, NI-CI) of acylated compounds.
Main Results:
- Acylation effectively protects OH, SH, and NH groups, increasing volatility and improving chromatographic separation.
- Mass spectral properties of acylated derivatives aid in compound identification, structure elucidation, and quantification.
- The review summarizes recent applications in synthetic organic, clinical, and environmental chemistry.
Conclusions:
- Acylation is a versatile and widely used derivatization strategy in analytical chemistry.
- Understanding the chemical and mass spectral properties of acylated derivatives is vital for accurate analysis.
- This technique offers significant advantages for analyzing diverse compounds across various scientific disciplines.