Migraine with aura related to the percutaneous closure of an atrial septal defect

Josep Rodés-Cabau1, Carlos Molina, Carmen Serrano-Munuera

  • 1Department of Cardiology, Hospital Universitari Vall d'Hebron, Barcelona, Spain. joseprodes@hotmail.com

Insights

Migraine with aura attacks occurred in a patient following atrial septal defect closure. Investigations for blood clots causing the migraine were negative, suggesting an alternative cause.

Area of Science:

  • Cardiology
  • Neurology
  • Medical Devices

Background:

  • Atrial septal defect (ASD) closure is a common procedure.
  • Transcatheter closure using devices like the Amplatzer septal occluder is a minimally invasive option.
  • Migraine with aura is a neurological condition characterized by sensory disturbances preceding a headache.

Observation:

  • A 31-year-old woman experienced recurrent migraine with aura attacks.
  • These attacks began within 48 hours after undergoing transcatheter closure of an atrial septal defect.
  • The Amplatzer septal occluder device was used for the closure procedure.

Findings:

  • The patient's migraine attacks with aura persisted for three months post-procedure.
  • Extensive examinations were conducted to investigate a potential thromboembolic (blood clot-related) origin for the migraines.
  • All diagnostic tests for thromboembolic causes returned negative results.

Implications:

  • This case suggests a possible, though unconfirmed, link between transcatheter ASD closure and the onset of migraine with aura.
  • The negative findings for thromboembolism highlight the need to consider other potential mechanisms or triggers for post-procedural migraines.
  • Further research is warranted to explore the relationship between cardiac procedures, device implantation, and neurological events like migraine.

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