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Updated: Aug 30, 2026

Echocardiographic Evaluation of Atrial Communications before Transcatheter Closure
Published on: February 8, 2022
Migraine with aura related to the percutaneous closure of an atrial septal defect
Josep Rodés-Cabau1, Carlos Molina, Carmen Serrano-Munuera
1Department of Cardiology, Hospital Universitari Vall d'Hebron, Barcelona, Spain. joseprodes@hotmail.com
Insights
Migraine with aura attacks occurred in a patient following atrial septal defect closure. Investigations for blood clots causing the migraine were negative, suggesting an alternative cause.
Area of Science:
- Cardiology
- Neurology
- Medical Devices
Background:
- Atrial septal defect (ASD) closure is a common procedure.
- Transcatheter closure using devices like the Amplatzer septal occluder is a minimally invasive option.
- Migraine with aura is a neurological condition characterized by sensory disturbances preceding a headache.
Observation:
- A 31-year-old woman experienced recurrent migraine with aura attacks.
- These attacks began within 48 hours after undergoing transcatheter closure of an atrial septal defect.
- The Amplatzer septal occluder device was used for the closure procedure.
Findings:
- The patient's migraine attacks with aura persisted for three months post-procedure.
- Extensive examinations were conducted to investigate a potential thromboembolic (blood clot-related) origin for the migraines.
- All diagnostic tests for thromboembolic causes returned negative results.
Implications:
- This case suggests a possible, though unconfirmed, link between transcatheter ASD closure and the onset of migraine with aura.
- The negative findings for thromboembolism highlight the need to consider other potential mechanisms or triggers for post-procedural migraines.
- Further research is warranted to explore the relationship between cardiac procedures, device implantation, and neurological events like migraine.
Abstract:
We report a case of a 31-year-old woman who presented migraine attacks with aura within the 48 hr after transcatheter closure of an atrial septal defect with the Amplatzer septal occluder device. The migraine attacks persisted for 3 months, and all examinations performed to rule out a thromboembolic origin of migraine were negative.
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