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Aplidiasterols A and B, two new cytotoxic 9,11-secosterols from the Mediterranean ascidian Aplidium conicum
Anna Aiello1, Giuseppe Esposito, Ernesto Fattorusso
1Dipartimento di Chimica delle Sostanze Naturali, Via Domenico Montesano 49, 80131, Napoli, Italy.
Abstract:
Two novel 9,11-secosterols, aplidiasterols A (3beta,6beta,11-trihydroxy-9,11-seco-5alpha-cholest-7-en-9-one, 1) and B (3beta,5alpha,6beta,11-tetrahydroxy-9,11-secocholest-7-en-9-one, 2), along with the known secosterols 3 and 4, were isolated from the Mediterranean ascidian Aplidium conicum and their structures were determined by spectroscopic data. Aplidiasterols A and B were found to be cytotoxic against rat glioma (C6) and murine monocyte/macrophage (J774) tumor cells in vitro. Compounds 1-4 represent the first example of secosterols isolated from tunicates.
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