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Updated: Aug 3, 2026

Measurement of the Hepatic Venous Pressure Gradient and Transjugular Liver Biopsy
Published on: June 18, 2020
Current therapy for nonvariceal upper gastrointestinal bleeding
J M Blocksom1, S Tokioka, C Sugawa
1Department of Surgery, Wayne State University, 6-C UHC, Detroit, MI 48201, USA.
Upper gastrointestinal bleeding remains a challenge. Current treatments combine endoscopic therapies like epinephrine injection with bicap or heater probe, while angiography is reserved for unsuccessful endoscopic interventions.
Area of Science:
- Gastroenterology
- Endoscopy
- Internal Medicine
Background:
- Upper gastrointestinal bleeding (UGIB) persists despite advances in treating peptic ulcer disease.
- Helicobacter pylori and novel medical therapies offer some hope for managing bleeding peptic ulcers.
Purpose of the Study:
- To review current diagnostic and treatment strategies for upper gastrointestinal bleeding.
- To highlight the role of endoscopic therapy and alternative interventions.
Main Methods:
- Review of current medical and endoscopic treatment modalities for UGIB.
- Discussion of combination endoscopic therapies and interventional radiology techniques.
Main Results:
- Endoscopic therapy is the primary method for diagnosing and treating UGIB.
- Combination therapy with epinephrine injection and bipolar electrocoagulation (bicap) or heater probe is common in the US.
- Angiography and embolization are utilized when endoscopic treatments fail.
Conclusions:
- Despite ongoing research and new medications, endoscopic therapy remains crucial for managing upper gastrointestinal hemorrhage.
- A combination of endoscopic techniques is the standard of care, with interventional radiology as a secondary option.
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