A convenient route to enantiomerically pure 2-substituted methyl glycerate derivatives
Steven V Ley1, Patrick Michel, Claudio Trapella
1Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK. svl1000@cam.ac.uk
Organic Letters
|November 25, 2003
Abstract:
[reaction: see text] The lithium enolate of a butanediacetal-protected glycerate derivative undergoes efficient and diastereoselective alkylation to afford a new fully substituted stereogenic center. These compounds may be elaborated to stable 2-substituted glyceraldehyde derivatives.
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