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Multicentric osteosarcoma with long-term survival.

Toshiaki Aizawa¹, Kyoji Okada, Eiji Abe

¹Department of Orthopedic Surgery, Akita University School of Medicine, 1-1-1 Hondo, 010-8543, Japan.

Skeletal Radiology

|November 25, 2003

Summary

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This case study details a rare multicentric osteosarcoma in a 14-year-old girl, highlighting her 9-year survival. Successful treatment involved chemotherapy and surgical excision of multiple bone tumors.

Area of Science:

Orthopedic Oncology
Pediatric Oncology
Skeletal Metastasis

Background:

Multicentric osteosarcoma is a rare variant of osteosarcoma characterized by simultaneous or sequential tumors in multiple bones.
Early diagnosis and aggressive treatment are crucial for managing this aggressive bone cancer.

Observation:

A 14-year-old female presented with right knee pain, revealing a destructive lesion in the distal femur.
Radiographs identified additional sclerotic lesions in the femur and humeri.
Biopsy confirmed multicentric osteosarcoma.

Findings:

Systemic chemotherapy (T-20) led to the disappearance of humeral lesions.
Surgical excision of primary femur lesions was performed.
Recurrent lesions in the iliac bone and lumbar vertebra were treated with chemotherapy and surgery.

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The patient achieved over 9 years of survival with no evidence of recurrence or metastasis at the latest follow-up.

Renal dysfunction emerged as a late complication.

Implications:

This case underscores the potential for long-term survival in multicentric osteosarcoma with multimodal therapy.
It highlights the importance of vigilant monitoring for treatment-related toxicities, such as renal dysfunction.
Further research into optimal treatment strategies and long-term management of multicentric osteosarcoma is warranted.