Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Small bowel transplantation - current status and initial results].

A R Müller1, A Pascher, K-P Platz

  • 1Klinik für Allgemeine- und Thoraxchirurgie, Universitätsklinikum Schleswig-Holstein, Campus Kiel. amueller@chirurgie-sh.de

Zentralblatt Fur Chirurgie
|November 25, 2003
PubMed
Summary

Small bowel transplantation survival rates have improved, with 80% 1-year survival for isolated transplants. However, complications like rejection and infections remain challenges, particularly in combined liver-small bowel procedures.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cannabidiol (Epidyolex®) for severe behavioral manifestations in patients with tuberous sclerosis complex, mucopolysaccharidosis type III and fragile X syndrome: protocol for a series of randomized, placebo-controlled N-of-1 trials.

BMC psychiatry·2024
Same author

[Transplantation for acute-on-chronic liver failure].

Chirurgie (Heidelberg, Germany)·2023
Same author

Radical Resection in Entero-Pancreatic Neuroendocrine Tumors: Recurrence-Free Survival Rate and Definition of a Risk Score for Recurrence.

Annals of surgical oncology·2022
Same author

Pancreatic Fistula and Biochemical Leak after Splenectomy: Incidence and Risk Factors-A Retrospective Single-Center Analysis.

Langenbeck's archives of surgery·2022
Same author

Methylphenidate for attention-deficit/hyperactivity disorder in patients with Smith-Magenis syndrome: protocol for a series of N-of-1 trials.

Orphanet journal of rare diseases·2021
Same author

[Machine perfusion for conditioning liver and kidneys before transplantation].

Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen·2020

Area of Science:

  • Gastroenterology
  • Transplantation Surgery
  • Immunology

Background:

  • Clinical small bowel transplantation has advanced, achieving 80% 1-year patient survival for isolated procedures.
  • Small bowel transplantation is less common in Germany due to high risks of acute rejection and associated complications, including infections.
  • Combined liver-small bowel transplantation is performed in patients with total parenteral nutrition-associated liver cirrhosis, but has lower survival rates (approx. 50% at 1 year).

Purpose of the Study:

  • To review the current status and challenges of clinical small bowel transplantation.
  • To highlight the impact of immunosuppression improvements on rejection rates.
  • To discuss the significance of viral infections, particularly EBV, and post-transplant lymphoproliferative disease (PTLD).

Main Methods:

Related Experiment Videos

  • Review of clinical outcomes and complication rates in small bowel transplantation.
  • Analysis of rejection incidence following immunosuppression advancements.
  • Monitoring and preemptive therapy strategies for viral infections like CMV and EBV.

Main Results:

  • 1-year patient survival for isolated small bowel transplants is 80%, with a decrease in acute rejection rates to below 25% due to improved immunosuppression.
  • Combined liver-small bowel transplants show lower patient survival (approx. 50% at 1 year) despite immunological advantages.
  • Epstein-Barr virus (EBV) infections are critically important as all post-transplant lymphoproliferative diseases observed were EBV-associated.

Conclusions:

  • Despite challenges, small bowel transplantation offers long-term survival (50% alive up to 15 years) and improved quality of life for many recipients.
  • Effective management of rejection and viral infections, including preemptive therapy, is crucial for successful outcomes.
  • Further research and improved strategies are needed to mitigate complications and enhance survival, especially for combined liver-small bowel transplants.