[Structural-biochemical reorganization of rat liver caused by hydrogen sulfide-containing gas mixture]

Morphological equivalents of hepatocyte response to environmental factors of various intensity, associated with biochemical processes and directed at cell survival were studied in white outbred male rat using morphological (light and electron microscopy, histoautoradiography) and biochemical methods. As judged by the responses of intracellular structures, an exposure to hydrogen sulfide-containing gas, a pathogenic environmental factor, results in unequal changes in hepatocytes in different lobule zones. Small doses cause an activation of metabolic processes in hepatocytes that have plastic directivity. High doses of hydrogen sulfide-containing gas mixture result in the appearance of some signs of hepatocyte adaptation to extreme situation. Positive dynamics of structural modifications of the liver after the administration of nootropil and vitamin complex with antioxidant properties as correcting substances, indicates the reversibility of hepatocyte changes following long-term (up to two weeks) exposure to low doses and short-term exposure to high doses of hydrogen sulfide-containing gas mixture.