Related Experiment Video
Updated: Aug 30, 2026

Repeated Measurement of Respiratory Muscle Activity and Ventilation in Mouse Models of Neuromuscular Disease
Published on: April 17, 2017
[Polymyositis with ventilatory incapacity and respiratory insufficiency]
Osvaldo López Gastón1, Eduardo Malvino, Diego Mc Loughlin
1División Terapia Intensiva, Policlínico Bancario, Buenos Aires, Argentina. odlogaston@hotmail.com
Abstract:
The inflammatory diseases of muscle are a group of disorders characterized by proximal muscle weakness. Most cases fall into three major diagnostic categories, polymyositis (PM), dermatomyositis and inclusion body myositis. Respiratory complications are a common feature and are an important cause of morbidity and mortality. The three main types of pulmonary involvement are interstitial lung disease, aspiration pneumonia and ventilatory incapacity (VI) due to muscle weakness. There are few reported cases in which mechanical ventilation has been used in patients with PM and VI in absence of lung disease. We present a patient with PM and VI due to muscle weakness who underwent therapy maintenance with mechanical ventilator and was weaned 4 months later.
Insights
Inflammatory muscle diseases like polymyositis can cause respiratory failure. This case study details successful mechanical ventilation and weaning in a polymyositis patient with ventilatory incapacity.
Area of Science:
- Neurology
- Pulmonology
- Rheumatology
Background:
- Inflammatory myopathies, including polymyositis (PM), cause proximal muscle weakness.
- Respiratory complications, such as ventilatory incapacity (VI), are significant causes of morbidity and mortality in these conditions.
- Pulmonary involvement in PM typically includes interstitial lung disease, aspiration pneumonia, or VI.
Observation:
- Mechanical ventilation is rarely reported for PM patients with VI but without lung disease.
- This report focuses on a patient diagnosed with polymyositis and VI solely due to muscle weakness.
Findings:
- The patient required mechanical ventilation for management of VI.
- Successful weaning from the mechanical ventilator was achieved after 4 months of therapy.
Implications:
- This case highlights the potential efficacy of mechanical ventilation in managing severe VI in polymyositis patients.
- It suggests that respiratory support can be a viable therapeutic option even in the absence of primary lung disease.
- Further research into respiratory management strategies for inflammatory myopathies is warranted.
Related Concept Videos
Acute Respiratory Failure-III
Acute Respiratory Failure-II
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
Acute Respiratory Failure-I
Definition: It is defined by specific criteria based on blood gas measurements. Hypoxemia happens when the partial pressure of oxygen (PaO2) falls below 60 mmHg. At the same time,...
Acute Respiratory Failure-V
Ensure that patients are monitored continuously for their response to therapy, including changes in...
Acute Respiratory Failure-IV
Respiratory Syncytial Virus Disease
