What's new and what's hot in transplantation: basic science ATC 2003

It has been approximately 50 years since the initial descriptions of acquired transplant tolerance, and our understanding of the immune response to a transplanted organ has progressed enormously during the ensuing years. Recent studies have shed new light on the molecular and cellular basis of transplant rejection, have better defined the mechanisms of allograft tolerance with particular emphasis on a role for regulatory T cells, have identified important new hurdles to overcome in order to prolong allograft survival, have brought xenotransplantation closer to becoming a clinical reality, and have led to the development of novel techniques that may permit analysis of immune responses to transplanted organs in vivo.