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Drug delivery systems: polymers and drugs monitored by capillary electromigration methods
Carolina Simó1, Alejandro Cifuentes, Alberto Gallardo
1Institute of Industrial Fermentations (CSIC), Juan de la Cierva 3, 28006 Madrid, Spain.
Summary
This review covers electromigration techniques for monitoring drug and polymer release from drug delivery systems. These methods offer an alternative to chromatography for analyzing controlled release applications.
Area of Science:
- Analytical Chemistry
- Materials Science
- Pharmaceutical Sciences
Background:
- Drug delivery systems (DDS) are crucial for targeted and controlled therapeutic agent release.
- Monitoring drug and polymer behavior within DDS is essential for efficacy and safety.
- Traditional analytical methods may have limitations in analyzing complex DDS matrices.
Purpose of the Study:
- To review electromigration methods for monitoring drug and polymer release from DDS.
- To introduce common DDS arrangements and electromigration principles.
- To compare electromigration with chromatographic techniques for DDS analysis.
Main Methods:
- Discussion of capillary electromigration procedures.
- Revision of methods for monitoring drug release.
- Revision of methods for monitoring polymer degradation/solubilization.
- Comparison with chromatographic methods.
Main Results:
- Electromigration techniques provide valuable insights into drug and polymer release kinetics.
- Capillary electromigration methods offer sensitive and efficient analysis of DDS components.
- Comparison highlights the strengths and weaknesses of electromigration versus chromatography.
Conclusions:
- Electromigration methods are promising for analyzing drug and polymer release from DDS.
- These techniques offer advantages for both in vitro and in vivo studies.
- Future applications in controlled release are anticipated with further development.