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Updated: Aug 30, 2026

Registered Bioimaging of Nanomaterials for Diagnostic and Therapeutic Monitoring
Published on: December 9, 2010
New magnetic resonance contrast agents as biochemical reporters
Thomas J Meade1, Alisha K Taylor, Steven R Bull
1Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, IL 60201-3113, USA. tmeade@northwestern.edu
Abstract:
Magnetic resonance imaging is a noninvasive, volume rendering diagnostic technique that uses lanthanide complexes to enhance proton relaxation. Magnetic resonance imaging is not limited by light scattering as optical microscopic techniques are, and allows imaging of whole animals. Clinical contrast agents are nonspecific and report solely on anatomy, whereas contrast agents that can be activated can be tailored to report on the physiological status or metabolic activity of biological systems. These new classes of magnetic resonance contrast agents represent a substantial leap in the type of information that can be derived from imaging experiments, and are the focus of this review.
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