Related Experiment Video
Updated: Aug 30, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
Synthesis and anti-measles virus activity of new isoquinolin-4-one derivatives
N A Santagati1, E Bousquet, A Garozzo
1Dipartimento di Scienze Farmaceutiche, Facolta di Farmacia, Università degli Studi di Catania, Viale Andrea Doria, 6, 95125 Catania, Italy. santagat@unict.it
Abstract:
Despite intense efforts to increase vaccine coverage, measles virus (MV) still causes significant morbidity and mortality in the world sometimes as a results of severe, chronic and lethal diseases. In an effort to develop therapies to supplement immunization strategies a number of 1-oxo-2-[[(1E)-phenylmethylene]amino]-1,2-dihydroisoquinoline-4-carboxylic acid derivatives were synthesized and evaluated for anti-measles activity. The substituents on the aromatic ring were chosen in order to evaluate the influence of electron-withdrawing or electron-donating effects on the electronic density of the aromatic moiety. We also evaluated the introduction of a vinyl chain between the exocyclic nitrogen and phenyl moiety. The biological results allow to outline some preliminary considerations on structure-activity relationship.
Related Concept Videos
Inhibitors of Bacterial DNA Synthesis
Antiviral Nucleoside Inhibitors
Aryldiazonium Salts to Azo Dyes: Diazo Coupling
![Solid-phase Synthesis of [4.4] Spirocyclic Oximes](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F58508.jpg&w=3840&q=50)
