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Testosterone supplementation for aging-associated sarcopenia.

Shalender Bhasin1

  • 1Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R. Drew University, Los Angeles, California 90059, USA. sbhasin@ucla.edu

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
|November 25, 2003
PubMed
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Testosterone therapy in older men with low levels can increase muscle mass and strength while reducing fat. However, its effects on physical function, disability, and long-term risks remain unknown.

Area of Science:

  • Gerontology
  • Endocrinology
  • Sports Medicine

Background:

  • Aging is linked to decreased muscle mass and function, and increased fat mass.
  • Low testosterone levels in older men correlate with reduced fat-free mass and muscle strength.
  • Testosterone replacement therapy (TRT) in older men with hypogonadism has shown benefits in body composition and strength.

Purpose of the Study:

  • To investigate the impact of TRT on physical function in older men with low testosterone.
  • To assess whether TRT reduces the risk of disability, falls, or fractures.
  • To evaluate the long-term risks and benefits of TRT in this population.

Main Methods:

  • Observational studies and clinical trials examining testosterone levels and body composition.

Related Experiment Videos

  • Intervention studies involving testosterone supplementation in older men.
  • Longitudinal studies tracking physical function, disability, falls, and fractures.

    • Main Results:

    • Epidemiologic data show a positive correlation between bioavailable testosterone and fat-free mass/muscle strength.
    • TRT in hypogonadal older men increases fat-free mass and muscle strength, and decreases fat mass.

    Conclusions:

    • While TRT improves body composition and strength in older men with low testosterone, its effects on physical function and health outcomes require further investigation.
    • The long-term safety and efficacy of TRT in older men are not yet established.