Pediatric gastroesophageal reflux disease--current perspectives

Jennifer Strople1, Ajay Kaul

  • 1Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Ohio 45228-3039, USA.

Insights

Gastroesophageal reflux disease (GERD) in children presents challenges. Newer diagnostic tools like impedance monitoring and treatments are emerging, but further research is needed for pediatric application.

Area of Science:

  • Pediatric Gastroenterology
  • Gastroesophageal Reflux Disease (GERD) Research
  • Diagnostic Modalities in Pediatrics

Background:

  • Gastroesophageal reflux disease (GERD) can manifest with atypical symptoms beyond heartburn and regurgitation.
  • Otolaryngologic and respiratory symptoms may be the sole indicators of GERD in pediatric patients.
  • Understanding GERD pathophysiology, diagnosis, and treatment is crucial for effective pediatric care.

Purpose of the Study:

  • To review recent advancements in GERD pathophysiology, diagnosis, and treatment.
  • To discuss the implications of these developments for pediatric GERD management.
  • To highlight the need for further research in pediatric GERD.

Main Methods:

  • Review of recent literature on GERD pathophysiology, diagnosis, and treatment.
  • Focus on newer diagnostic modalities such as intraesophageal impedance and Bravo wireless pH monitoring.
  • Evaluation of emerging therapeutic options and endoluminal therapies.

Main Results:

  • Impedance technology offers insights into both acid and non-acid reflux.
  • Bravo wireless pH monitoring allows for prolonged monitoring under physiological conditions.
  • Higher dosages of acid suppressive therapy may be required for pediatric GERD response.
  • Endoluminal therapies show promise in adults but have limitations for pediatric use.

Conclusions:

  • Impedance monitoring enhances understanding of reflux but lacks established pediatric norms.
  • Current endoluminal therapies are not yet widely applicable to children.
  • Further research is essential to validate new diagnostic and therapeutic approaches for pediatric GERD.
Abstract

Related Concept Videos

Gastroesophageal Reflux Disease II: Clinical Features and Management01:29

Gastroesophageal Reflux Disease II: Clinical Features and Management

Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
Gastroesophageal Reflux Disease I: Meaning and Pathophysiology01:29

Gastroesophageal Reflux Disease I: Meaning and Pathophysiology

Gastroesophageal Reflux Disease (GERD) involves the recurrent backflow of the stomach or duodenal contents into the esophagus, leading to troublesome symptoms and potential esophageal mucosal damage. Although GERD is often referred to as a disease, it is more accurately described as a syndrome, as it encompasses a range of symptoms and complications rather than a singular pathological entity, impacting a large number of individuals as the most prevalent upper gastrointestinal problem. Roughly...
Gastroesophageal Reflux Disease01:25

Gastroesophageal Reflux Disease

Gastroesophageal reflux disease (GERD) is the backward flow of stomach contents (acid, pepsin, or bile) into the esophagus, causing mucosal inflammation known as esophagitis. It results from failure of antireflux mechanisms, mainly the lower esophageal sphincter (LES), influenced by mechanical and physiological factors.Etiology and Risk FactorsGERD develops when LES function is weakened or when intra-abdominal pressure increases. Risk factors include aging, obesity, and sliding hiatal hernia,...
Esophageal Strictures-II: Clinical Features and Management01:26

Esophageal Strictures-II: Clinical Features and Management

Patients with esophageal strictures often experience a range of symptoms. Initially, they may have difficulty swallowing solid foods, which can progress to include liquids. Additional symptoms may involve chest pain or discomfort, regurgitating food and fluids, heartburn, unintentional weight loss, coughing or choking during meals, and hoarseness.
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
Esophageal Strictures-I: Introduction01:30

Esophageal Strictures-I: Introduction

Esophageal strictures involve abnormal narrowing or tightening of the esophagus. They vary in length and severity, ranging from mild constriction to complete obstruction, and are classified as benign (noncancerous) or malignant (cancerous).
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
Barrett Esophagus-II: Clinical Manifestations and Management01:21

Barrett Esophagus-II: Clinical Manifestations and Management

Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure entails...