Related Experiment Video
Updated: Aug 30, 2026

Simultaneous Laryngopharyngeal and Conventional Esophageal pH Monitoring
Published on: December 14, 2020
Pediatric gastroesophageal reflux disease--current perspectives
1Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Ohio 45228-3039, USA.
Insights
Gastroesophageal reflux disease (GERD) in children presents challenges. Newer diagnostic tools like impedance monitoring and treatments are emerging, but further research is needed for pediatric application.
Area of Science:
- Pediatric Gastroenterology
- Gastroesophageal Reflux Disease (GERD) Research
- Diagnostic Modalities in Pediatrics
Background:
- Gastroesophageal reflux disease (GERD) can manifest with atypical symptoms beyond heartburn and regurgitation.
- Otolaryngologic and respiratory symptoms may be the sole indicators of GERD in pediatric patients.
- Understanding GERD pathophysiology, diagnosis, and treatment is crucial for effective pediatric care.
Purpose of the Study:
- To review recent advancements in GERD pathophysiology, diagnosis, and treatment.
- To discuss the implications of these developments for pediatric GERD management.
- To highlight the need for further research in pediatric GERD.
Main Methods:
- Review of recent literature on GERD pathophysiology, diagnosis, and treatment.
- Focus on newer diagnostic modalities such as intraesophageal impedance and Bravo wireless pH monitoring.
- Evaluation of emerging therapeutic options and endoluminal therapies.
Main Results:
- Impedance technology offers insights into both acid and non-acid reflux.
- Bravo wireless pH monitoring allows for prolonged monitoring under physiological conditions.
- Higher dosages of acid suppressive therapy may be required for pediatric GERD response.
- Endoluminal therapies show promise in adults but have limitations for pediatric use.
Conclusions:
- Impedance monitoring enhances understanding of reflux but lacks established pediatric norms.
- Current endoluminal therapies are not yet widely applicable to children.
- Further research is essential to validate new diagnostic and therapeutic approaches for pediatric GERD.
Purpose Of Review:
Although heartburn and regurgitation are common manifestations of gastroesophageal reflux disease (GERD), otolaryngologic or respiratory symptoms may be the only indication of GERD. This review focuses on the recent developments in the pathophysiology, diagnosis, and treatment of GERD and their implications in pediatrics.
Recent Findings:
Newer diagnostic modalities include intraesophageal impedance and Bravo wireless pH monitoring. Impedance technology measures both acid and non-acid reflux, whereas the Bravo capsule allows prolonged pH monitoring under more physiologic conditions. In managing children with GERD, there is increasing evidence that they need higher dosages of acid suppressive therapy to achieve clinical response. Alternative therapeutic options are also currently being explored, including pharmacotherapy that targets the primary mechanism for GERD. Endoluminal therapy for GERD in adults as an alternative to surgery has been an exciting development. At present, two of these procedures, Stretta (using radiofrequency energy) and Endocinch (gastroplication), have been approved by the Food and Drug Administration for use in adults.
Summary:
Impedance technology has increased our understanding of acid and nonacid reflux; however, normal values for children are not yet established. There are also limitations to the applicability of the new endoluminal therapies in children. Further research is needed before these developments can be recommended for use in pediatric practice.
Related Concept Videos
Gastroesophageal Reflux Disease II: Clinical Features and Management
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
Gastroesophageal Reflux Disease I: Meaning and Pathophysiology
Gastroesophageal Reflux Disease
Esophageal Strictures-II: Clinical Features and Management
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
Esophageal Strictures-I: Introduction
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
Barrett Esophagus-II: Clinical Manifestations and Management
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure entails...

