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Computation of HORRAT values.

Foster D McClure¹, Jung-Keun Lee

¹U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Scientific Analysis and Support, Division of Mathematics, 5100 Paint Branch Pkwy, College Park, MD 20740-3835, USA. fmcclure@cfsan.fda.gov

Journal of AOAC International

|November 25, 2003

Summary

The Horwitz ratio (HORRAT) calculation is inaccurate for trace analyte concentrations. New methods are presented to ensure correct HORRAT values in analytical chemistry, improving data reliability.

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Area of Science:

Analytical Chemistry
Metrology

Background:

The Horwitz ratio (HORRAT) is a key metric for assessing method performance in analytical chemistry.
The standard HORRAT formula is derived from the AOAC INTERNATIONAL Study Director's Manual.
Current limitations exist in HORRAT applicability for specific concentration units.

Purpose of the Study:

To address the inaccuracies in the standard Horwitz ratio calculation when dealing with trace analyte concentrations.
To present alternative calculation procedures for accurate HORRAT determination in mass fraction or trace amount contexts.

Main Methods:

The study identifies the limitations of the existing HORRAT formula.
Alternative calculation methodologies are developed and presented.
The applicability of these new methods is discussed for various concentration units.

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Main Results:

The conventional HORRAT formula yields incorrect values for trace concentrations (e.g., microg/g).
Alternative procedures provide accurate HORRAT calculations for trace and mass fraction amounts.
The proposed methods ensure reliable assessment of analytical method performance across different concentration scales.

Conclusions:

The standard HORRAT calculation is insufficient for trace concentration analysis.
Alternative HORRAT calculation methods are essential for accurate method performance evaluation.
Implementing these alternative procedures enhances the reliability of analytical data in diverse applications.