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Updated: Jul 26, 2026

Analysis of Cell Cycle Position in Mammalian Cells
12:19

Analysis of Cell Cycle Position in Mammalian Cells

Published on: January 21, 2012

Roles of cyclin D1 and related genes in growth inhibition, senescence and apoptosis

E K Han1, S C Ng, N Arber

  • 1Herbert Irving Comprehensive Cancer Center, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA. Edward.K.Han@Abbott.Com

Apoptosis : an International Journal on Programmed Cell Death
|November 25, 2003
PubMed

Insights

Cyclin D1 plays a key role in cell cycle control, influencing cell growth, senescence, and apoptosis. Its diverse effects depend on expression levels and cell context, mediated by cyclin-dependent kinase pathways.

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Cancer Research

Background:

  • Apoptosis (programmed cell death) is intrinsically linked to cell cycle regulation.
  • Specific factors during cell cycle phases, such as cyclin D1, p53, p21WAF1, and p27kip1, influence apoptosis.
  • Premature Cdk1 activation in G2/M phases can trigger mitotic catastrophe and apoptosis.

Purpose of the Study:

  • To review the role of factors acting during the G1 and S phases of the cell cycle.
  • To focus on cyclin D1's multifaceted effects on cell growth, senescence, and apoptosis.
  • To explore the mechanisms underlying cyclin D1's diverse cellular impacts.

Main Methods:

  • Literature review focusing on cell cycle regulation and apoptosis.
  • Analysis of the role of cyclin D1 in various cellular processes.
  • Discussion of cyclin-dependent kinase (CDK)-dependent and -independent pathways.

Main Results:

  • Cyclin D1 exhibits diverse effects on cell growth, senescence, and apoptosis.
  • These effects are contingent upon cyclin D1 expression levels, cell type, and cellular context.
  • Both CDK-dependent and -independent mechanisms contribute to cyclin D1's functions.

Conclusions:

  • Cyclin D1 is a critical regulator of cell fate decisions during the G1 and S phases.
  • Understanding cyclin D1's context-dependent roles is crucial for comprehending cell cycle control and apoptosis.
  • Further research into CDK-dependent and -independent pathways will elucidate cyclin D1's precise functions.

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