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Related Experiment Videos

CD14 and apoptosis.

C D Gregory1, A Devitt

  • 1Institute of Cell Signalling and School of Biomedical Sciences, University of Nottingham Medical School, Queen's Medical Centre, Nottingham, NG7 2UH, UK. Chris.Gregory@nottingham.ac.uk

Apoptosis : an International Journal on Programmed Cell Death
|November 25, 2003
PubMed
Summary
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The macrophage receptor CD14 (cluster of differentiation 14) binds bacterial products to trigger inflammation and also clears apoptotic cells without inducing inflammation. This dual role highlights CD14

Area of Science:

  • Immunology
  • Cell Biology
  • Biochemistry

Background:

  • The 55kDa glycoprotein CD14 (cluster of differentiation 14) is a macrophage plasma membrane receptor involved in innate immunity.
  • CD14 mediates pro-inflammatory responses upon binding bacterial lipopolysaccharide (LPS).
  • Emerging evidence indicates CD14's role in the clearance of apoptotic cells.

Purpose of the Study:

  • To review the structure and functions of CD14.
  • To explore CD14's ligands and signal transduction pathways.
  • To elucidate CD14's role in apoptotic cell clearance by macrophages.

Main Methods:

  • Literature review of existing studies on CD14.
  • Analysis of CD14's interactions with lipopolysaccharide (LPS) and apoptotic cell ligands.

Related Experiment Videos

  • Comparison of inflammatory responses triggered by LPS versus apoptotic cell binding.

    • Main Results:

    • CD14 binds both microbial products (like LPS) and self-components on apoptotic cells.
    • Ligand binding for apoptotic cells occurs at or near the LPS-binding site.
    • CD14-mediated apoptotic cell clearance does not induce pro-inflammatory cytokine release, unlike LPS binding.

    Conclusions:

    • CD14 functions as a dual innate immune receptor.
    • It recognizes microbial products to initiate inflammatory responses.
    • It recognizes self-components on apoptotic cells to facilitate non-inflammatory clearance.