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Cytokeratin-positive interstitial cell neoplasm: a case report and classification issues
K Schuerfeld1, S Lazzi, M M De Santi
1Department of Human Pathology and Oncology, Siena University, Siena, Italy.
Histopathology
|November 26, 2003
Summary
This case report details a rare tumour of cytokeratin-positive interstitial reticulum cells (CIRCs) in a lymph node. Awareness is crucial to prevent misdiagnosis as metastatic carcinoma.
Area of Science:
- Oncology
- Pathology
- Immunohistochemistry
Background:
- Tumours of dendritic/accessory cell origin are rare lymph node neoplasms.
- Cytokeratin-positive interstitial reticulum cell (CIRC) tumours are exceptionally infrequent.
- The International Lymphoma Study Group classification omits CIRC tumours.
Observation:
- A case of a CIRC tumour in a 66-year-old male's submandibular lymph node is presented.
- The neoplasm featured spindle cells with specific nuclear and cytoplasmic characteristics.
- Tumour cells exhibited a distinct immunophenotype including S100, vimentin, desmin, lysozyme, and focal cytokeratins.
Findings:
- The tumour cells displayed diffuse S100, vimentin, desmin, and lysozyme positivity.
- Focal positivity for CD68 and various cytokeratins (7, 8, 18, CK-AE1, CK-pool) was observed.
- Electron microscopy revealed characteristic cytoplasmic projections and rudimentary cell junctions.
Implications:
- Histopathologists must recognize CIRC tumours to avoid misdiagnosis.
- Differential diagnosis should include metastatic carcinoma.
- Thorough clinical and pathological assessment is essential for accurate diagnosis.