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Texture analysis of hippocampal sclerosis

Leonardo Bonilha1, Eliane Kobayashi, Gabriela Castellano

  • 1Department of Neurology, Medical School, State University of Campinas, Cidade Universitária Zeferino Vaz, Campinas, SP, CEP 13083-970, Brazil.

Epilepsia
|November 26, 2003
PubMed
Abstract

Insights

MRI texture analysis can detect hippocampal abnormalities in patients with hippocampal sclerosis (HS), a common feature of mesial temporal lobe epilepsy (MTLE). While texture analysis showed differences between affected and healthy hippocampi, it did not distinguish between affected and contralateral hippocampi.

Area of Science:

  • Neurology
  • Radiology
  • Medical Imaging

Background:

  • Mesial temporal lobe epilepsy (MTLE) often presents with difficult-to-treat seizures.
  • Hippocampal sclerosis (HS) is a common pathological finding in MTLE.
  • Quantitative MRI techniques show promise for detecting and measuring HS.

Purpose of the Study:

  • To assess if MRI texture analysis can identify hippocampal abnormalities in patients with pathologically confirmed HS.
  • To evaluate the utility of texture analysis in the context of MTLE and HS.

Main Methods:

  • Texture analysis was performed on preoperative 3-mm coronal T1-IR MRIs of the hippocampal head in 19 patients with surgically treated MTLE and histopathologically diagnosed HS.
  • The software MAZDA was used for texture analysis.
  • Data were compared to 78 normal hippocampi from 39 healthy volunteers using multivariate analysis of variance.

Main Results:

  • Texture analysis parameters largely differentiated hippocampi with HS and contralateral hippocampi from normal hippocampi.
  • However, post hoc comparisons revealed no significant differences between the HS hippocampi and their contralateral counterparts.
  • This suggests widespread changes beyond the primarily affected side.

Conclusions:

  • MRI texture analysis provides evidence of altered texture in hippocampi affected by HS.
  • The findings support the hypothesis that hippocampal damage in MTLE may be bilateral.
  • Further research is required to determine the effectiveness of texture analysis in lateralizing hippocampal damage in MTLE.

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