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Related Experiment Videos

A new process for making reservoir-type microcapsules using ink-jet technology and interfacial phase separation.

Yoon Yeo1, Osman A Basaran, Kinam Park

  • 1Departments of Pharmaceutics and Biomedical Engineering, Purdue University, West Lafayette, IN 47907-2051, USA.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|November 26, 2003
PubMed
Summary

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A novel microencapsulation method uses solvent exchange between liquids to create reservoir-type microcapsules. This technique, utilizing a dual microdispenser system, offers a new way to produce advanced drug delivery systems.

Area of Science:

  • Materials Science
  • Chemical Engineering
  • Pharmaceutical Technology

Background:

  • Microencapsulation is crucial for drug delivery, requiring precise control over capsule formation.
  • Existing methods often face limitations in efficiency, scalability, or control over microcapsule structure.

Purpose of the Study:

  • To develop a novel microencapsulation technique based on interfacial phenomena.
  • To create reservoir-type microcapsules with unique geometries using a dual microdispenser system.
  • To establish methods for selecting appropriate solvents for the new technique.

Main Methods:

  • Developed a microencapsulation technique utilizing interfacial mass transfer (solvent exchange) between two mutually soluble liquids.
  • Employed a dual microdispenser system with two ink-jet nozzles to generate colliding droplets of polymer and aqueous solutions.

Related Experiment Videos

  • Implemented screening methods to identify suitable organic solvents for polymer film formation.

    • Main Results:

    • Successfully formed reservoir-type microcapsules by inducing solvent exchange at the interface of colliding droplets.
    • Demonstrated that polymer membrane formation depends on solvent spreading and exchange rate, with ethyl acetate identified as a desirable solvent.
    • Microscopic examination confirmed the unique geometry of the fabricated microcapsules.

    Conclusions:

    • The developed interfacial mass transfer technique offers a novel and efficient approach for microencapsulation.
    • The dual microdispenser system combined with judicious solvent selection enables precise formation of unique microcapsule structures.
    • This method holds potential for advanced applications in drug delivery and other fields requiring controlled microencapsulation.