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Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
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Challenges and innovations in long-acting injectable formulations: can formulation design space be rationalized?
Andrew Otte1, Kinam Park1,2, Tonglei Li2
1Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, United States.
The Journal of Pharmacy and Pharmacology
|September 29, 2025
Summary
Selecting drugs for long-acting injectable (LAI) formulations can be guided by drug properties. A systematic approach using the drug
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery Systems
- Biotechnology
Background:
- Over 70 long-acting injectable (LAI) formulations exist, with many using oily solutions for poorly soluble drugs.
- Hydrophilic drugs, nucleic acids, peptides, and proteins require different formulation strategies, often using poly(lactide-co-glycolide) polymers.
Purpose of the Study:
- To identify guiding principles for selecting appropriate drug candidates for LAI formulations.
- To examine historical advancements and challenges in LAI development to predict successful drug candidates.
Main Methods:
- Analysis of drug properties including water solubility, lipophilicity, tissue permeability, half-life, and effective dosage in relation to LAI development.
- Investigation of parameters to forecast formulation success, focusing on the balance between the drug's partition coefficient (logP) and effective dose.
Main Results:
- Drug properties like logP and effective dose are key indicators for LAI formulation success.
- An optimal balance between lipophilicity (logP) and effective dose is crucial for predicting formulation viability.
Conclusions:
- A systematic screening approach integrating logP and effective dose can improve the probability of successful LAI formulation.
- This approach aids in the preliminary selection of drugs with higher potential for successful clinical application in LAI systems.
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