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Phytanic acid alpha-oxidation in human cultured skin fibroblasts

I Singh¹, O Lazo, P Kalipada

¹Department of Pediatrics, Medical University of South Carolina, Charleston 29425.

Biochimica Et Biophysica Acta

|December 10, 1992

Abstract:

We studied the oxidation of [1-14C]phytanic acid, 3-methyl substituted fatty acid, to pristanic acid and 14CO2 in human skin fibroblasts. The specific activity for alpha-oxidation of phytanic acid in peroxisomes was 29- and 124-fold higher than mitochondria and endoplasmic reticulum. This finding demonstrates for the first time the presence of fatty acid alpha-oxidation enzyme system in peroxisomes.

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