Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Eukaryotic domain evolution inferred from genome comparisons.

Richard R Copley1, Leo Goodstadt, Chris Ponting

  • 1Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.

Current Opinion in Genetics & Development
|November 26, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sponges, ctenophores, and the statistical significance of syntenies.

Molecular biology and evolution·2025
Same author

The structure of an actin nucleus stabilized by villin.

Science advances·2025
Same author

Chromosome-scale genome assembly and gene annotation of the hydrothermal vent annelid Alvinella pompejana yield insight into animal evolution in extreme environments.

BMC biology·2025
Same author

Aboral cell types of <i>Clytia</i> and coral larvae have shared features and link taurine to the regulation of settlement.

Science advances·2025
Same author

Insights into early animal evolution from the genome of the xenacoelomorph worm <i>Xenoturbella bocki</i>.

eLife·2024
Same author

Early transcriptional similarities between two distinct neural lineages during ascidian embryogenesis.

Developmental biology·2024
Same journal

Temporal trajectories underlying adult neuronal diversity.

Current opinion in genetics & development·2026
Same journal

Transcription regulation of cell fate plasticity - from embryonic development to tissue regeneration.

Current opinion in genetics & development·2026
Same journal

Shared molecular and cellular programs during regeneration of glandular epithelia.

Current opinion in genetics & development·2026
Same journal

Lineage tracing in human cortical development.

Current opinion in genetics & development·2026
Same journal

Cis-regulatory strategies in developmental patterning.

Current opinion in genetics & development·2026
Same journal

GABAergic neuron fate specification and lineage allocation: from development to disorder.

Current opinion in genetics & development·2026
See all related articles

Gene duplication drives domain family evolution in eukaryotes, outpacing new domain emergence. Lineage-specific families likely result from duplication and diversification, reflecting adaptation through organismal competition.

Area of Science:

  • Evolutionary biology
  • Genomics
  • Molecular evolution

Background:

  • Comparative genomic analyses reveal insights into eukaryotic genome evolution.
  • Gene duplication is a primary mechanism for the expansion of protein domain families.

Purpose of the Study:

  • To investigate the mode and tempo of protein domain family evolution in eukaryotes.
  • To understand the relationship between gene duplication, domain family expansion, and adaptation.

Main Methods:

  • Comparative analysis of eukaryotic genomes.
  • Examination of gene duplication rates versus domain emergence and recruitment rates.
  • Analysis of lineage-specific domain families.

Main Results:

Related Experiment Videos

  • Gene duplication occurs at a higher rate than the emergence of new domains or their recruitment into novel architectures.
  • Domain families restricted to specific lineages are often products of gene duplication and rapid sequence diversification.
  • The functions of these families likely relate to adaptation driven by inter-organismal competition.

    • Conclusions:

    • Gene duplication is the dominant force shaping protein domain family evolution in eukaryotes.
    • Lineage-specific domain families represent adaptations potentially driven by competitive selection.
    • Understanding domain evolution provides insights into the mechanisms of evolutionary adaptation.