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Related Experiment Videos

Solvent compatibility of poly(dimethylsiloxane)-based microfluidic devices.

Jessamine Ng Lee1, Cheolmin Park, George M Whitesides

  • 1Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA.

Analytical Chemistry
|December 4, 2003
PubMed
Summary
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Poly(dimethylsiloxane) (PDMS) compatibility with organic solvents is crucial for microfluidic devices. Swelling is the primary factor, with solvents like water showing minimal interaction and others like xylenes causing significant swelling.

Area of Science:

  • Materials Science
  • Chemical Engineering
  • Microfluidics

Background:

  • Poly(dimethylsiloxane) (PDMS) is widely used in microfluidic devices.
  • Understanding PDMS compatibility with organic solvents is essential for applications like microreactors.
  • Solvent interactions can affect device performance and longevity.

Purpose of the Study:

  • To investigate the compatibility of PDMS with various organic solvents.
  • To determine the key factors influencing PDMS-solvent interactions.
  • To assess the feasibility of using PDMS microfluidic devices for organic reactions.

Main Methods:

  • Experimental measurement of PDMS swelling in different solvents.
  • Correlation of swelling data with solubility parameters (delta) and cohesive energy densities (c).

Related Experiment Videos

  • Demonstration of a Diels-Alder reaction within a PDMS microchannel.

    • Main Results:

    • PDMS swelling varied significantly with solvent choice.
    • Solvents like water, nitromethane, and acetonitrile showed minimal swelling.
    • Solvents such as diisopropylamine, triethylamine, pentane, and xylenes caused substantial swelling.
    • Swelling was found to be the most influential factor in PDMS-solvent compatibility.
    • Highly swelling solvents effectively removed contaminants and altered PDMS surface properties.

    Conclusions:

    • PDMS exhibits tunable compatibility with organic solvents, primarily governed by swelling.
    • The solubility parameter effectively predicts PDMS swelling behavior.
    • PDMS microfluidic devices are suitable for specific organic reactions, demonstrated by the Diels-Alder reaction.
    • Careful solvent selection is necessary to optimize PDMS microfluidic device performance and applications.