Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Replacement therapy in Addison's disease.

Kristian Løvås, Eystein S Husebye

    Expert Opinion on Pharmacotherapy
    |December 4, 2003
    PubMed
    Summary
    This summary is machine-generated.

    Addison's disease, or primary adrenal insufficiency, results from autoimmune adrenal cortex destruction. Current hormone replacement therapy for cortisol and aldosterone deficiency may not fully restore physiological levels, impacting patient well-being.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Immunotherapy for Fertility in Autoimmune Premature Ovarian Insufficiency.

    NEJM evidence·2026
    Same author

    Long-term follow-up of autoimmune polyendocrine syndrome type 1 in Norway.

    The Journal of clinical endocrinology and metabolism·2026
    Same author

    Aire-dependent interferon signalling shapes thymocyte maturation and central tolerance in mice.

    Communications biology·2025
    Same author

    EndoCompass Project: Research Roadmap for Adrenal and Cardiovascular Endocrinology.

    Hormone research in paediatrics·2025
    Same author

    Immune Checkpoint Inhibitor Endocrinopathies-Insights From 3 Unusual Cases.

    JCEM case reports·2025
    Same author

    EndoCompass project: research roadmap for adrenal and cardiovascular endocrinology.

    European journal of endocrinology·2025
    Same journal

    Pharmacotherapeutic interventions for pediatric ulcerative colitis.

    Expert opinion on pharmacotherapy·2026
    Same journal

    The rise and fall of TRPV1-targeted analgesia in osteoarthritis: a critical appraisal.

    Expert opinion on pharmacotherapy·2026
    Same journal

    Dopamine transporter and beyond: evolving targets and combination strategies in stimulant use disorder.

    Expert opinion on pharmacotherapy·2026
    Same journal

    GnRH antagonists for the treatment of fibroids and adenomyosis, current evidence and future perspectives.

    Expert opinion on pharmacotherapy·2026
    Same journal

    Pharmacotherapeutic strategies for the management of congenital adrenal hyperplasia.

    Expert opinion on pharmacotherapy·2026
    Same journal

    Current advances in pharmacotherapeutic strategies for the treatment of complicated intra-abdominal infections.

    Expert opinion on pharmacotherapy·2026
    See all related articles

    Area of Science:

    • Endocrinology
    • Autoimmune Diseases
    • Pharmacology

    Background:

    • Addison's disease (primary adrenal insufficiency) stems from autoimmune adrenal cortex destruction, leading to cortisol and aldosterone deficiency.
    • Adrenal androgen depletion also occurs, though its clinical significance remains unclear.
    • Current treatment involves glucocorticoid and mineralocorticoid replacement, which fails to mimic natural diurnal hormone variations.

    Discussion:

    • Standard replacement therapy for Addison's disease may cause fatigue, reduced stress tolerance, and potential bone metabolism issues due to glucocorticoid over-replacement.
    • The review examines current drug and dosage recommendations for hydrocortisone, cortisone acetate, and fludrocortisone.
    • The efficacy of dehydroepiandrosterone replacement in adrenal failure is weakly supported by evidence.

    Related Experiment Videos

    Key Insights:

    • Current hormone replacement therapies for Addison's disease do not replicate physiological diurnal hormone rhythms.
    • Patients on standard therapy report persistent symptoms like fatigue and reduced stress resilience.
    • Concerns exist regarding glucocorticoid over-replacement's impact on bone metabolism and androgen deficiency.

    Outlook:

    • Further research is needed to understand the long-term consequences of current replacement therapy.
    • Optimizing hormone replacement strategies to better mimic physiological patterns is crucial.
    • Investigating the role and potential benefits of adrenal androgen replacement requires more robust evidence.