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Hormones of the Adrenal Glands01:31

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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
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EndoCompass Project: Research Roadmap for Adrenal and Cardiovascular Endocrinology.

Eystein S Husebye1,2, Guillaume Assié3,4, Nils Krone5

  • 1Department of Clinical Science, University of Bergen, Bergen, Norway, eystein.sverre.husebye@helse-bergen.no.

Hormone Research in Paediatrics
|November 27, 2025
PubMed
Summary

Strategic research priorities for adrenal disorders were identified to improve hormone health. This roadmap focuses on enhancing diagnostics, therapies, and understanding disease mechanisms to reduce the impact of adrenal conditions.

Keywords:
AdrenalAdrenal insufficiencyAdrenal tumoursCardiovascularEndoCompassEndocrine hypertensionFundingRoadmap

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Area of Science:

  • Endocrinology
  • Adrenal Science
  • Hormone Health

Background:

  • Endocrine science is underrepresented in EU research funding.
  • A gap exists between the societal impact of endocrine disorders and research prioritization.
  • The EndoCompass project aims to define strategic research priorities in endocrinology.

Purpose of the Study:

  • To identify and promote strategic research priorities in endocrine science.
  • To address critical hormone-related health challenges.
  • To provide a roadmap for research investment in adrenal disorders.

Main Methods:

  • Analysis of the EU CORDIS database (Horizon 2020).
  • Expert consultation in adrenal endocrinology.
  • Stakeholder engagement with society members and patient groups.

Main Results:

  • Identified research priorities for adrenal disorders: insufficiency, tumors, and hypertension.
  • Key areas include biomarker development, replacement therapies, and disease mechanisms.
  • Emphasis on personalized treatment and pan-European registries.

Conclusions:

  • The EndoCompass project offers a roadmap for strategic research investment in adrenal disorders.
  • Identified areas for investigation into pathophysiology, prevention, and treatment.
  • Aims to reduce the burden of adrenal disorders and align research funding with high-impact areas.