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In Vivo Imaging and Tracking of Technetium-99m Labeled Bone Marrow Mesenchymal Stem Cells in Equine Tendinopathy
Published on: December 9, 2015
Tc-99m HMPAO-labeled leukocytes for hematopoietic marrow imaging. Comparison with In-111 chloride
T Aburano1, K Yokoyama, N Shuke
1Department of Nuclear Medicine, Kanazawa University Hospital, Japan.
Clinical Nuclear Medicine
|December 1, 1992
Summary
Technetium-99m (Tc-99m) leukocyte imaging shows potential for evaluating bone marrow hematopoietic activity in diffuse hematologic disorders. This nuclear medicine technique may offer valuable insights, particularly for granulopoietic activity assessment.
Area of Science:
- Nuclear Medicine
- Hematology
- Oncology
Background:
- Assessing bone marrow hematopoietic activity is crucial in diagnosing and managing diffuse hematologic disorders.
- Current imaging techniques may have limitations in providing comprehensive information on bone marrow cellularity.
Purpose of the Study:
- To compare Technetium-99m (Tc-99m) leukocyte imaging with Indium-111 (In-111) chloride imaging.
- To determine if Tc-99m leukocyte imaging offers additional information on bone marrow hematopoietic activity in patients with diffuse hematologic disorders.
Main Methods:
- A comparative study involving 11 patients diagnosed with hematologic disorders.
- Both Tc-99m leukocyte and In-111 chloride imaging were performed on all participants.
- Bone marrow biopsy and aspiration were used to confirm hematopoietic cellularity.
Main Results:
- One patient with myelofibrosis exhibited differing tracer distributions: decreased Tc-99m leukocyte uptake centrally versus expanded In-111 chloride marrow.
- This discrepancy correlated with biopsy findings of granuloid hypoplasia and erythroid hyperplasia.
- The remaining 10 patients showed concordant tracer distribution, aligning with bone marrow biopsy results.
Conclusions:
- Tc-99m leukocyte imaging demonstrates potential as an effective agent for evaluating bone marrow hematopoietic activity.
- The technique appears particularly useful for assessing granulopoietic activity in the context of hematologic disorders.
