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Avian HSC emergence, migration, and commitment toward the T cell lineage

Thierry Jaffredo1, Sandrine Alais, Karine Bollerot

  • 1UMR CNRS 7622, Université Pierre et Marie Curie, 9, Quai St Bernard, 75005 Paris, France.

FEMS Immunology and Medical Microbiology
|December 4, 2003
PubMed

To date three sites of emergence of hemopoietin cells have been identified during early avian development: the yolk sac, the intraaortic clusters and recently the allantois. However, the contributions of the hematopoietic stem cell (HSC) populations generated by these different sites to definitive hematopoiesis and their migration routes are not fully unraveled. Experimental embryology as well as the establishment of the genetic cascades involved in HSC emergence help now to draw a better scheme of these processes.

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