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Diabetic neuropathies.

A I Vinik1, M T Holland, J M Le Beau

  • 1Diabetic Neuropathy Study Group, Eastern Virginia Medical School, Norfolk 23510.

Diabetes Care
|December 1, 1992
PubMed
Summary
This summary is machine-generated.

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Diabetic neuropathy, a common diabetes complication, causes significant morbidity and mortality. Early blood glucose control may delay nerve damage, but reversibility is unproven and requires understanding disease mechanisms.

Area of Science:

  • Neurology
  • Endocrinology
  • Diabetology

Background:

  • Diabetic neuropathy is a frequent diabetes complication, leading to significant morbidity and mortality.
  • Its epidemiology and natural history are unclear due to inconsistent definitions and measurements.
  • Clinical manifestations involve both somatic and autonomic nervous systems.

Purpose of the Study:

  • To review clinical manifestations of diabetic neuropathy.
  • To discuss current management strategies for diabetic neuropathy.
  • To highlight the need for improved understanding of pathogenesis and measurement.

Main Methods:

  • Literature review of clinical manifestations.
  • Discussion of current management approaches.
  • Analysis of evidence regarding blood glucose control and neuropathy.

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Main Results:

  • Near-normal blood glucose control early in diabetes may delay nerve impairment.
  • Intensive glucose normalization might reverse early neuropathy, though evidence is limited.
  • Understanding pathogenic processes is crucial for effective management.

Conclusions:

  • Effective management of diabetic neuropathy hinges on understanding its underlying causes.
  • The vascular hypothesis offers new therapeutic investigation avenues.
  • Standardized, validated quantitative tests are essential for accurate measurement and comparability.