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Epithelial-mesenchymal transitions in development and pathologies.

Jean Paul Thiery1

  • 1Unite Mixte de Recherche 144, Centre National Recherche Scientifique, Institut Curie, 26 rue d'Ulm, 75248 Paris cedex 05, France. jpthiery@curie.fr

Current Opinion in Cell Biology
|December 4, 2003
PubMed
Summary

The epithelial-mesenchymal transition (EMT) is crucial for development and disease, involving conserved molecular pathways. Research defines mesenchymal cells and their ancient evolutionary origins.

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Area of Science:

  • Developmental Biology
  • Cell Biology
  • Evolutionary Biology

Background:

  • The epithelial-mesenchymal transition (EMT) is a fundamental biological process.
  • EMT plays a role in morphogenesis, development, and diseases like fibrosis and cancer.
  • Understanding EMT mechanisms is key to addressing pathological conditions.

Purpose of the Study:

  • To elucidate the molecular mechanisms underlying EMT.
  • To define the characteristics of mesenchymal cells.
  • To explore the evolutionary significance of EMT.

Main Methods:

  • Studies primarily utilized epithelial cell lines to investigate EMT.
  • In vivo studies in various species confirmed conserved EMT mechanisms.
  • Molecular and functional analyses were employed to characterize mesenchymal cells.

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Main Results:

  • Key transduction pathways driving EMT were identified.
  • Loss of epithelial polarity and acquisition of mesenchymal traits were observed.
  • EMT mechanisms were found to be conserved across species.

Conclusions:

  • EMT is a critical, evolutionarily conserved process.
  • Mesenchymal cells, originating over 500 million years ago, are vital.
  • Further research enhances the molecular and functional definition of EMT and mesenchymal cells.