Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

How low can you get?

M Brincat1, Y Muscat Baron, R Galea

  • 1University of Malta, Department of Obstetrics and Gynaecology, Medical School G'Mangia, Malta. mpbrincat@keyworld.net

Annals of the New York Academy of Sciences
|December 3, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Primary standardization, half-life determination, and γ-ray emission probability of <sup>233</sup>Pa at NRC.

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine·2026
Same author

Monte Carlo sensitivity analysis of the Vinten 671 ionization chamber activity calibration coefficients.

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine·2026
Same author

A benchmark for Monte Carlo simulations in gamma-ray spectrometry Part II: True coincidence summing correction factors.

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine·2023
Same author

Primary standardization and half-life determination of <sup>225</sup>Ac at NRC.

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine·2023
Same author

Production of a carrier-free standard <sup>56</sup>Mn source for the NRC manganese salt bath.

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine·2019
Same author

The first official measurement of <sup>11</sup>C in the SIRTI.

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine·2019
Same journal

Multiomics Profiling During Autoimmune Demyelination Highlights a Complex Regulatory Role for Ataxin-1 in B Cells.

Annals of the New York Academy of Sciences·2026
Same journal

Global Trends in Light Pollution and Their Relationship With Socioeconomic Factors.

Annals of the New York Academy of Sciences·2026
Same journal

Wired for Corruption: Inter-Brain Synchrony Encodes Bribery-Related Value Information and Predicts Bribery Agreement.

Annals of the New York Academy of Sciences·2026
Same journal

LM-YOLO: A Lightweight Multi-Scale Enhanced Model for Forest Smoke Detection Using Unmanned Aerial Vehicles.

Annals of the New York Academy of Sciences·2026
Same journal

Polyrhythm Perception and Production: A Scoping Review.

Annals of the New York Academy of Sciences·2026
Same journal

DARTS-CNN-BiLSTM: Intelligent Fault Diagnosis for Computer Numerical Control Machine Tool Feed System.

Annals of the New York Academy of Sciences·2026
See all related articles

New low-dose oral contraceptives containing ethinyl estradiol and gestodene demonstrate reduced side effects and maintain contraceptive efficacy. This 24-day regimen shows promise for improved patient compliance and a satisfactory Pearl index.

Area of Science:

  • Reproductive Health
  • Endocrinology
  • Pharmacology

Background:

  • Oral contraceptives (OCs) historically used high doses of ethinyl estradiol (EE), leading to known side effects.
  • Research efforts have focused on dose reduction of both estrogen and progestin components in OCs.
  • Maintaining contraceptive efficacy, indicated by the Pearl index, is crucial during dose reduction.

Purpose of the Study:

  • To evaluate a novel low-dose oral contraceptive regimen.
  • To assess the safety and efficacy of a 24-day regimen containing 15 microg EE and 60 microg gestodene.
  • To determine if dose reduction impacts contraceptive efficacy and side effect profile.

Main Methods:

  • An open-label, noncomparative, multicenter study.
  • Inclusion of a 24-day regimen of a low-dose oral contraceptive pill.

Related Experiment Videos

  • Monitoring of contraceptive efficacy (Pearl index) and reported side effects.

    • Main Results:

    • The low-dose pill (15 microg EE and 60 microg gestodene) demonstrated a satisfactory Pearl index.
    • The regimen showed potential for reducing contraceptive-related side effects.
    • Improved patient compliance is anticipated with this formulation.

    Conclusions:

    • The 24-day low-dose oral contraceptive regimen appears to effectively balance reduced side effects with maintained contraceptive efficacy.
    • This formulation represents a promising advancement in oral contraceptive development.
    • Further research may confirm enhanced patient compliance and a favorable safety profile.