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Intimate evolution of proteins. Proteome atomic content correlates with genome base composition
Peggy Baudouin-Cornu1, Katja Schuerer, Philippe Marlière
1Centre de Génétique Moléculaire, Centre National de la Recherche Scientifique, 91 198 Gif sur Yvette, France.
The Journal of Biological Chemistry
|December 3, 2003
Summary
This study reveals significant variations in protein atomic composition across species, particularly carbon content. A strong correlation exists between genome base composition and proteome carbon, suggesting natural selection influences genome evolution.
Area of Science:
- Biochemistry
- Evolutionary Biology
- Genomics
Background:
- Understanding biopolymer evolution requires analyzing genome sequence relationships.
- Protein atomic composition is a key factor in evolutionary modeling.
Purpose of the Study:
- To systematically analyze the atomic composition of proteins across different kingdoms.
- To investigate the relationship between proteome and genome composition.
Main Methods:
- Systematic analysis of protein atomic composition in representative organisms.
- Comparative analysis of bulk and ortholog protein subsets.
- Correlation analysis between proteome carbon and genome base composition (G+C content).
- Generation of random proteomes and examination of the genetic code.
Main Results:
- Significant variations in protein atomic composition, especially carbon, were observed among species.
- High G+C genome content correlated with low protein carbon content.
- Ortholog protein subsets also exhibited these compositional variations.
Conclusions:
- Natural selection may have driven genome base composition to influence protein atomic content.
- The findings provide insights into the evolutionary pressures shaping genomes and proteomes.