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Related Experiment Videos

Primate antisaccade. II. Supplementary eye field neuronal activity predicts correct performance.

Nelly Amador1, Madeleine Schlag-Rey, John Schlag

  • 1Department of Neurobiology and Brain Research Institute, University of California School of Medicine, Los Angeles, California 90095-1763, USA.

Journal of Neurophysiology
|December 3, 2003
PubMed
Summary

The supplementary eye field (SEF) is crucial for antisaccades, with eye-movement neurons firing more before these voluntary eye movements than during reflexive prosaccades.

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Area of Science:

  • Neuroscience
  • Ophthalmology
  • Cognitive Science

Background:

  • The supplementary eye field (SEF) plays a role in voluntary eye movements.
  • Antisaccades are voluntary eye movements toward a location opposite a visual stimulus, contrasting with reflexive prosaccades.
  • Understanding SEF's role in antisaccade generation is key to comprehending executive control of gaze.

Purpose of the Study:

  • To investigate the involvement of the supplementary eye field (SEF) in the production of antisaccades.
  • To analyze the activity of SEF neurons during both antisaccade and prosaccade tasks.

Main Methods:

  • Neuronal activity was recorded from 3 macaque monkeys performing interleaved antisaccade and prosaccade tasks.
  • Analysis focused on visual, eye-movement, and instruction/fixation neurons within the SEF.

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  • Neuronal firing rates were examined in relation to saccade performance and task conditions.

    • Main Results:

    • 73% of SEF eye-movement-related neurons exhibited significantly higher firing rates before antisaccades compared to prosaccades.
    • Single-trial analysis revealed that eye-movement neuron firing rates 40 ms before a saccade predicted successful antisaccade performance.
    • Fixation neurons consistently fired more on antisaccade trials during the instruction period, though significance varied.

    Conclusions:

    • The supplementary eye field (SEF) is critically involved in the generation of antisaccades.
    • Specific patterns of SEF neuronal activity differentiate antisaccade from prosaccade execution.
    • SEF activity, particularly of eye-movement neurons, is a strong predictor of successful antisaccade performance.