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Updated: Aug 30, 2026

Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers
18:57

Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers

Published on: October 17, 2013

Transepithelial transport of p-coumaric acid and gallic acid in Caco-2 cell monolayers

Yutaka Konishi1, Shoko Kobayashi, Makoto Shimizu

  • 1Applied Bioresearch Center, Research & Development Department, Kirin Brewery Co., Ltd., Gunma, Japan. konishiy@kirin.co.jp

Bioscience, Biotechnology, and Biochemistry
|December 4, 2003
PubMed

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Pore Transport and Ion-Pair Transport

Pore transport and ion-pair formation are critical mechanisms for the absorption and distribution of drugs in the body.
Pore transport, also known as convective transport, is a process where small molecules like urea, water, and sugars rapidly cross cell membranes as though there were channels or pores in the membrane. Although direct microscopic evidence is limited  but the concept of pores or channels is widely accepted based on physiological evidence. Despite the lack of direct microscopic...
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Transcellular Transport of Solutes

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Cellular Membranes and Drug Transport

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