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Updated: Aug 30, 2026

Behavioral Characterization of Pentylenetetrazole-induced Seizures: Moving Beyond the Racine Scale
Published on: July 8, 2025
Carbamazepine, clonazepam and focal reflex proprioceptive seizures
GianPietro Sechi1, Davide Corda, Giovanni A Deiana
1Department of Neurology, University of Sassari, Neurological Clinic, Viale S. Pietro 10, 07100-Sassari, Italy. gpsechi@ssmain.uniss.it
Abstract:
We studied a 34-year-old man with focal tonic-clonic seizures sometimes elicited by some active postures of the right hand and evolving at times to secondary generalization. Treatment with carbamazepine (CBZ) in combination with parenteral diazepam induced both a dramatic increase of focal reflex proprioceptive seizures and choreoathetoid dyskinesias in the affected hand. CBZ was withdrawn and clonazepam (CZP) given 2 mg daily, with complete relief of seizures and choreoathetoid dyskinesias. CZP had a suppressive effect on seizures for over 15 years, without development of tolerance.
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