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Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism
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Diastolic regional wall motion asynchrony in patients with hypertension

K S Sunnerhagen1, V Bhargava

  • 1University of California, San Diego.

International Journal of Cardiac Imaging
|January 1, 1992
PubMed

Insights

Hypertension can cause abnormal heart wall motion, particularly in the apex, even without coronary artery disease. Treating high blood pressure may reverse these diastolic regional asynchronies.

Area of Science:

  • Cardiology
  • Cardiovascular Physiology

Background:

  • Left ventricular regional wall motion analysis is crucial for understanding cardiac function.
  • Hypertension and coronary artery disease are significant risk factors for cardiovascular abnormalities.

Purpose of the Study:

  • To investigate the impact of hypertension on left ventricular regional wall motion, with and without coronary artery disease.
  • To determine the relationship between coronary artery lesions and regional wall motion abnormalities.

Main Methods:

  • Analysis of angiographic ventriculograms in 51 subjects (controls, hypertensive with CAD, hypertensive without CAD).
  • Categorization of hypertensive patients without CAD into normotensive, borderline, and hypertensive groups.
  • Assessment of regional wall motion synchronicity and identification of affected cardiac regions.

Main Results:

  • Coronary artery lesions were the primary determinant of regional abnormality in hypertensive patients with CAD (83% sensitivity, 95% specificity).
  • Diastolic regional asynchrony was detected in 14 of 15 hypertensive patients without CAD, with the apical region most commonly affected.
  • Normotensive and some borderline hypertensive patients without CAD exhibited normal wall motion.

Conclusions:

  • Hypertension, even without coronary artery disease, can lead to diastolic regional asynchrony in left ventricular wall motion.
  • The apical region is frequently affected in hypertensive patients with wall motion abnormalities.
  • Treatment of hypertension may be important for potentially reversing abnormal wall motion.

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