Related Experiment Video
Updated: Aug 30, 2026

Sexual Transmission of American Trypanosomes from Males and Females to Naive Mates
Published on: January 27, 2019
[Congenital syphilis: an emerging emergency also in Brazil]
1Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre, RS, Brazil.
Insights
Congenital syphilis is often missed in newborns, leading to severe illness presentation in emergency rooms. Increased physician awareness of risk factors and diverse symptoms is crucial for timely diagnosis.
Area of Science:
- Pediatrics
- Infectious Diseases
- Public Health
Background:
- Congenital syphilis (CS) diagnosis is frequently delayed, with infants presenting in emergency departments with severe manifestations.
- Rising syphilis incidence in Brazil necessitates improved recognition of CS beyond the neonatal period.
Purpose of the Study:
- To underscore the issue of underdiagnosed congenital syphilis in newborns.
- To emphasize the importance of emergency physicians recognizing CS manifestations in infants.
Main Methods:
- Retrospective chart review of 3 patients with late-diagnosed CS.
- Literature review of Medline and Lilacs databases (1988-1999) on CS.
Main Results:
- Three infants diagnosed with CS after the neonatal period presented with severe conditions: neurosyphilis, nephrotic syndrome, and hepatitis.
- Analysis identified reasons for missed neonatal diagnosis and risk factors for gestational syphilis.
Conclusions:
- Emergency physicians require heightened suspicion for CS, considering maternal risk factors and diagnostic challenges.
- Awareness of diverse CS clinical presentations in the first months of life is critical for prompt intervention.
Abstract:
OBJECTIVE: To highlight to the fact that some newborns are not identified as having congenital syphilis, and will present to an emergency room within a few months with a severe disease. METHOD: Review of the charts concerning 3 patients with congenital syphilis, as well as review of the literature using Medline and Lilacs databases, covering the period from 1988 to 1999. RESULTS: We describe the case of 3 infants whose diagnosis of congenital syphilis was only established after the neonatal period, when they presented to the emergency room and were admitted to the pediatric intensive care unit. The first patient had neurosyphilis and nephrotic syndrome, the second had neurosyphilis, and the third had hepatitis. We discuss the clinical aspects of the cases, and comment on other clinical manifestations of congenital syphilis that should be within the purview of pediatric emergency medicine. We analyze the reasons for the failure to diagnose syphilis at birth, and describe some risk factors for gestational syphilis. CONCLUSIONS: Considering the rising incidence of syphilis in Brazil, and the possibility that the congenital infections are not recognized at birth, emergency physicians must keep a high degree of suspicion and an awareness of maternal risk factors, prenatal serology pitfalls, as well as of the several clinical presentations of congenital syphilis that can develop in the first months of life.
Related Concept Videos
Sexually Transmitted Infections
American Trypanosomiasis
Leishmaniasis
Infectious Diseases and Their Occurrence
Genital Herpes
Amebiasis

