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Updated: Aug 30, 2026
Cell Population Analyses During Skin Carcinogenesis
Published on: August 21, 2013
[Therapeutic and histological features of basaloid squamous cell carcinoma]
K Helling1, C Loddenkemper, H Scherer
1Universitäts-HNO-Klinik, Klinikum Benjamin Franklin, Freien Universität Berlin. kai.helling@medizin.fu-berlin.de
Background And Objective:
Basaloid squamous cell carcinoma s a rare, highly malignant carcinoma variant typically situated in the tongue base, supraglottis and pyriform sinus. It is usually only diagnosed at a very advanced stage due to its tendency towards submucosal growth, deep infiltration and early local and distant metastases.
Patients/Methods:
The case described involves a 39-year-old man with the clinical and histopathological findings typical for this neoplasm.
Results:
In contrast to simple squamous cell carcinomas, the basaloid variant with its very poor prognosis calls for therapeutic decisions that give particular consideration to quality of life. It should be stressed that highly invasive surgery is justified only in exceptional cases because of the high local recurrence rate and early distant metastases.
Conclusions:
The case presented shows that radio- and chemotherapeutic approaches are just as important as surgery.
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