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Related Experiment Videos

Isotope-dilution ICP-MS for trace element determination and speciation: from a reference method to a routine method?

Klaus G Heumann1

  • 1Institute of Inorganic Chemistry and Analytical Chemistry, Johannes Gutenberg-University Mainz, 55099 Mainz, Germany. heumann@mail.uni-mainz.de

Analytical and Bioanalytical Chemistry
|December 3, 2003
PubMed
Summary

Inductively coupled plasma-isotope dilution mass spectrometry (ICP-IDMS) offers high potential for routine trace element analysis when accuracy is paramount. However, hyphenated ICP-IDMS methods face challenges with isotope-labeled spikes and complex setups.

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Area of Science:

  • Analytical Chemistry
  • Mass Spectrometry
  • Environmental Science

Background:

  • Inductively coupled plasma-isotope dilution mass spectrometry (ICP-IDMS) is a powerful technique for elemental analysis.
  • Its application in routine trace element and element-speciation analysis requires careful consideration of specific conditions.
  • Existing hyphenated ICP-IDMS techniques face limitations due to the availability of labeled spike compounds and system complexity.

Purpose of the Study:

  • To critically review the suitability of ICP-IDMS for routine trace element and element-speciation analysis.
  • To evaluate the potential and limitations of ICP-IDMS based on recent and unpublished data.
  • To demonstrate the significance of isotope-labeled spike synthesis and potential interferences for ICP-IDMS applications.

Main Methods:

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  • Critical review of existing literature and unpublished investigations.
  • Application of ICP-IDMS for trace element determination.
  • Coupling of chromatography (GC/LC) with ICP-MS for speciation analysis.
  • Analysis of silicon, monomethylmercury, Cr(VI), and iodinated hydrocarbons.

Main Results:

  • ICP-IDMS is highly suitable for routine trace element analysis when result accuracy is the primary concern.
  • Hyphenated ICP-IDMS techniques are limited by the availability of isotope-labeled spikes and system complexity.
  • Species-specific ICP-IDMS coupled with chromatography enables validation of methods involving species transformations.
  • A novel microwave-assisted isotope dilution method for monomethylmercury determination shows potential for routine application.

Conclusions:

  • ICP-IDMS demonstrates significant potential for routine trace element analysis, particularly when high accuracy is required.
  • Challenges remain for hyphenated ICP-IDMS techniques, especially concerning isotope-labeled spike availability and system setup.
  • Species-specific ICP-IDMS, particularly when coupled with chromatography, offers unique capabilities for validating analytical methods involving species transformations.
  • Developments in sample pretreatment and spike synthesis, such as for monomethylmercury, enhance the routine applicability of ICP-IDMS.