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Related Experiment Video

Updated: Jun 25, 2026

Extraction and Analysis of Taiwanese Green Propolis

Extraction and Analysis of Taiwanese Green Propolis

Published on: January 7, 2019

Antimicrobial compounds from Pimpinella species growing in Turkey.

Nurhayat Tabanca¹, Erdal Bedir, Nese Kirimer

¹Department of Pharmacognosy, Faculty of Pharmacy, Anadolu University, Eskisehir, Turkey.

|December 4, 2003

Summary

Researchers isolated novel compounds from Pimpinella species, revealing significant antimicrobial activity against Mycobacterium intracellulare. These natural products offer potential for new therapeutic agents.

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Area of Science:

Natural Product Chemistry
Medicinal Chemistry
Pharmacognosy

Background:

The Pimpinella genus, particularly species endemic to Turkey like Pimpinella isaurica, is a source of diverse bioactive compounds.
Phenylpropanoids and sesquiterpenes are classes of natural products known for various biological activities.

Purpose of the Study:

To isolate and characterize new and known chemical constituents from Pimpinella isaurica, P. aurea, and P. corymbosa.
To evaluate the antimalarial and antimicrobial potential of the isolated compounds.

Main Methods:

Isolation of compounds using chromatographic techniques.
Structure elucidation of novel compounds employing advanced Nuclear Magnetic Resonance (NMR) spectroscopy (1D and 2D) and Liquid Chromatography-Electrospray Ionization-Fourier Transform Mass Spectrometry (LC-ESI-FTMS).
Bioactivity screening, including antimicrobial assays against Mycobacterium intracellulare.

Main Results:

A new phenylpropanoid, 4-(2-propenyl)-phenyl angelate (1), and a new sesquiterpene, 1-methyl-4-(5-methyl-1-methylenehex-4-enyl)-7-oxabicyclo[4.1.0]heptane (6), were identified.
Several known phenylpropanoids (2-5, 7, 8) were also isolated.
Compounds 1, 2, 4, 6, and 8 demonstrated significant antimicrobial activity against Mycobacterium intracellulare, with IC50 values ranging from 1.5 to 15.0 microg/mL.

Conclusions:

The study successfully identified novel chemical entities from Pimpinella species.
The isolated compounds, particularly compound 8, exhibit potent antimicrobial properties against Mycobacterium intracellulare, suggesting their therapeutic potential.