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[Episodes of depression with attempted suicide after taking valsartan with hydrochlorothiazide]
H Ullrich1, P Passenberg, M W Agelink
1Klinik für Psychiatrie, Psychotherapie und Psychosomatik, Evangelische Kliniken Gelsenkirchen, Germany. heiko.ullrich@ruhr-uni-bochum.de
History And Clinical Findings:
A 43-year-old woman was admitted after a suicide attempt with 1.5 g atenolol. Physical and neurological examination showed no abnormality, but psychiatric examination revealed symptoms of a major depression. Four weeks prior to admission a valsartan-hydrochlorothiazide combination had been added to the antihypertensive medication.
Investigations:
Laboratory tests, electrocardiography, chest-x-ray, electroencephalography and cranial computerised tomography showed no abnormality.
Diagnosis And Course:
The depressive disorder resolved within ten days after discontinuation of valsartan and hydrochlorothiazide without specific treatment. Blood pressure was normal under treatment with metoprolol.
Conclusion:
Depressive drug reactions can produce a substantial morbidity. This case of a drug induced affective disorder should heighten the awareness of unusual reactions to valsartan-hydrochlorothiazide therapy.
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