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Updated: Jul 17, 2026

A 3D Human Lung Tissue Model for Functional Studies on Mycobacterium tuberculosis Infection
Published on: October 5, 2015
[Issues addressed by tuberculosis in France in 2003]
1Service des maladies infectieuses et tropicales, Hôpital Bichat, 46, rue Henri Huchard, 75018 Paris, France. elisabeth.bouvet@bch.ap-hop.paris.fr
Abstract:
The incidence of tuberculosis in France has not declined since 4 years. In fact, there is a constant decline in the whole country but a slight increase in the Paris region. As in other big cities in the world, the recent increase in cases in Paris is mainly due to immigrants. In contrast, HIV coinfection accounts for a small and decreasing part of the cases. Moreover, the rates of resistance and multiresistance to antituberculous drugs are low and stable indicating that the treatment of active diseases is satisfactory. The respective part of cases due either to primary infections or to reactivations is unknown. In order to control tuberculosis in Paris, we need to implement better infection control policy with active screening of contacts of patients with active tuberculosis as well as treatment of latent tuberculosis infections.
Insights
Tuberculosis incidence in France is stable, with a rise in Paris primarily linked to immigration. Effective drug resistance management is noted, but enhanced control strategies are needed.
Area of Science:
- Public Health
- Epidemiology
- Infectious Diseases
Context:
- Tuberculosis (TB) incidence in France has remained stable over the past four years.
- While national TB rates show a constant decline, the Paris region has experienced a slight increase.
- This rise in Paris, mirroring trends in other global cities, is largely attributed to immigrant populations.
Purpose:
- To analyze current tuberculosis trends in France, particularly in the Paris region.
- To identify key drivers of tuberculosis incidence, including demographic factors and coinfections.
- To evaluate the effectiveness of current treatment strategies and recommend improvements for tuberculosis control.
Summary:
- The study highlights a concerning increase in tuberculosis cases within the Paris region, contrasting with a national decline.
- Immigration is identified as the primary driver for the rise in Parisian TB cases, while HIV coinfection's role is diminishing.
- Low and stable rates of drug resistance and multidrug resistance suggest satisfactory treatment outcomes for active tuberculosis.
Impact:
- The findings underscore the need for targeted public health interventions in urban centers like Paris.
- Implementing enhanced infection control policies, including active contact screening and latent TB treatment, is crucial for future tuberculosis control.
- Understanding the specific drivers of TB in different regions is essential for effective disease management and prevention strategies.
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