Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Biomimetic studies on polyenes.

John E Moses1, Jack E Baldwin, Sébastien Brückner

  • 1The Dyson Perrins Laboratory, University of Oxford, Oxford, UK OX1 3QY.

Organic & Biomolecular Chemistry
|December 3, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genetic and pharmacological inactivation of peptidoglycan remodeling increases antibiotic susceptibility of vancomycin-resistant Enterococcus faecium.

Nature communications·2026
Same author

Genetic and pharmacological inactivation of peptidoglycan remodeling increases antibiotic susceptibility of vancomycin-resistant <i>Enterococcus faecium</i>.

bioRxiv : the preprint server for biology·2026
Same author

Click chemistry for natural product-inspired covalent drug discovery.

Drug discovery today·2025
Same author

Strategic re-engineering of antibiotics.

Nature reviews bioengineering·2025
Same author

Phosphorus Fluoride Exchange (PFEx) Click Chemistry: 2-Substituted-alkynyl-1-cyclotriphosphazene (SACP) Hubs for Diversity Oriented Clicking.

Advanced synthesis & catalysis·2025
Same author

Benzene-1,3-disulfonyl fluoride and Benzene-1,3,5-trisulfonyl fluoride: Low-Cost, Stable, and Selective Reagents for SuFEx-Driven Deoxyazidation.

Advanced synthesis & catalysis·2025
Same journal

Catalytic synthesis of saturated azacycles using transborylation.

Organic & biomolecular chemistry·2026
Same journal

Pyridines with adamantane fragments and their 1,2,4-triazine analogues as anti-quorum-sensing agents, synthesis and molecular docking.

Organic & biomolecular chemistry·2026
Same journal

Synthesis of polymethylene-linked bis(cyclobutane-fused chromanones) mediated by gold photocatalysis.

Organic & biomolecular chemistry·2026
Same journal

Palladium-catalyzed chelation-assisted C-H functionalization of quinoline aldehydes to esters with mechanistic insights.

Organic & biomolecular chemistry·2026
Same journal

One-pot metal-free access to uracil-benzofuran bis-heterocycles: synthesis and DFT insights.

Organic & biomolecular chemistry·2026
Same journal

Transition-metal-free three-component synthesis of α-tertiary trifluoromethyl phosphonates from CF<sub>3</sub> diazo compounds.

Organic & biomolecular chemistry·2026
See all related articles

Researchers synthesized complex polypropionate natural products, crispatenes and SNF4435 C&D, from a single precursor. Varying reaction conditions allowed for easy preparation of core structures and unnatural analogs, offering biosynthetic insights.

Area of Science:

  • Natural Product Synthesis
  • Organic Chemistry
  • Biosynthesis

Background:

  • Crispatenes and SNF4435 C&D are complex polypropionate natural products.
  • Their intricate structures present synthetic challenges.

Purpose of the Study:

  • To develop a versatile synthetic route to crispatenes and SNF4435 C&D.
  • To explore the preparation of unnatural analogs.
  • To gain insights into the biosynthesis of these natural products.

Main Methods:

  • Utilized a common polyene precursor.
  • Manipulated reaction conditions to control product formation.

Main Results:

  • Successfully synthesized the core structures of crispatenes and SNF4435 C&D.

Related Experiment Videos

  • Generated complex unnatural structures from the same precursor.
  • Demonstrated the efficiency of varying reaction conditions.

    • Conclusions:

    • A common polyene precursor can yield diverse polypropionate natural products.
    • Synthetic accessibility of these compounds is enhanced.
    • The study provides valuable insights into natural product biosynthesis pathways.