Related Experiment Video
Updated: Aug 30, 2026

Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission
Published on: August 16, 2018
[Agmatine--an endogenous ligand of imidazoline receptors]
1Department of Fundamental Medicine, Moscow State University, Lomonosovskii pr. 31/5, Moscow, 117192 Russia.
Abstract:
The existence of imidazoline receptors was suggested based on the results of investigation of the central hypotensive action of the alpha 2-adrenoreceptor agonist clonidine containing imidazoline group in the molecule structure. Experiments on the rostral venterolateral medulla oblongata (RVLM) neurons in rats showed that not less that 36% of specific binding sites in this zone differ from adrenergic and recognize imidazoline derivatives. Agmatine has proved to be an endogenous ligand of such imidazoline receptors.
Related Concept Videos
Direct-Acting Cholinergic Agonists: Chemistry and Structure-Activity Relationship
The direct-acting...
Cholinergic Receptors: Muscarinic
The subtypes M1, M3, and M5 couple with the Gq subunit and activate the phospholipase C (PLC) activity, mobilizing intracellular Ca2+. Activation...
Cholinergic Antagonists: Chemistry and Structure-Activity Relationship
Adrenergic Agonists: Direct-Acting Agents
These agents can be classified...
Ligand-Gated Ion Channel Receptor: Gating Mechanism
Adrenergic Agonists: Indirect-Acting Agents
One mechanism involves depleting stored catecholamines by displacing them from synaptic vesicles. These agents, known as "displacers," are transported into vesicles at the expense of noradrenaline. Examples include amphetamine and tyramine, which lack a catechol moiety, resulting in prolonged action, improved oral bioavailability, and...

