Related Experiment Video
Updated: Aug 30, 2026

Acupoint Application as a Traditional Chinese Medicine Treatment for Fatigue Associated with Chronic Obstructive Pulmonary Disease
Published on: September 5, 2025
Fatigue and endocrine disorders. Causes and comorbidities
1Mater Adult Hospital, South Brisbane, Queensland. amorton@mater.org.au
Background:
Most causes of fatigue are ill defined, self limiting or elude diagnosis. Many endocrine disorders present with nonspecific features including fatigue, so are difficult to differentiate on clinical grounds. However, avoiding diagnostic delay is vital to prevent significant morbidity and mortality. Thus, a high index of suspicion and knowledge of appropriate investigations is important. Endocrine disorders predispose the individual to developing related disorders; fatigue may be one sign of associated comorbidity.
Objective:
This article discusses the endocrine disorders that commonly present with or develop fatigue as a prominent feature, with emphasis on particular challenges for diagnosis, investigation or management. Screening recommendations for comorbid disease was generated by an extensive review of current evidence.
Discussion:
The identification of endocrine disorders can be both challenging--due to patterns of presentation--and rewarding for doctors and patients alike, due to importance and effectiveness of treatment.
Related Concept Videos
Hyperthyroidism II: Pathophysiology
Adrenal Gland Disorders
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
Hypothyroidism II: Pathophysiology
Cushing Syndrome I: Introduction
Graves Disease II: Pathophysiology
Type II Diabetes I: Introduction